Go as Big as you can find .... you wont hurt your valves here so long as you use the proper fuel .... If you start doing crazy stuff like decking the head to increase your squeeze then you will have to start to measure your clearences along with going with a BIG Cam Shaft, but your valves will be fine and your piston will have to be cut out around your vavles for it to clear ....
Only thing that will hurt your valves is TIME and ABUSE (which too much time is ABUSE) ....
OH YEAH .... Benifits .... GREAT Throttle response, with great bottom end power yet still have the over rev that most Big Bores dont give you ... Compression just gives you more power EVERYWHERE when it comes down to it ....